Which extra-articular manifestation is commonly associated with Ankylosing Spondylitis?

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Multiple Choice

Which extra-articular manifestation is commonly associated with Ankylosing Spondylitis?

Ankylosing Spondylitis often extends beyond the joints, and the most common extra-articular manifestation is anterior uveitis (iritis) of the eye. This ocular inflammation is linked to the same inflammatory processes and HLA-B27 association that drive the spine and sacroiliac joint disease. It typically presents with eye pain, redness, photophobia, and sometimes blurred vision, and it requires prompt evaluation by an eye specialist; treatment is usually topical steroids with pupil-dilating drops, and addressing the underlying inflammatory activity helps prevent flares. While tendon enthesitis can occur in AS, and asthma or kidney stones can appear in other contexts, anterior uveitis remains the classic, most frequent extra-articular manifestation in this condition.

Ankylosing Spondylitis often extends beyond the joints, and the most common extra-articular manifestation is anterior uveitis (iritis) of the eye. This ocular inflammation is linked to the same inflammatory processes and HLA-B27 association that drive the spine and sacroiliac joint disease. It typically presents with eye pain, redness, photophobia, and sometimes blurred vision, and it requires prompt evaluation by an eye specialist; treatment is usually topical steroids with pupil-dilating drops, and addressing the underlying inflammatory activity helps prevent flares. While tendon enthesitis can occur in AS, and asthma or kidney stones can appear in other contexts, anterior uveitis remains the classic, most frequent extra-articular manifestation in this condition.

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